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Category: wellness& habits

  • Serotonin neurotransmitter – health implications beyond mental wellness

     It is a well-known fact that serotonin is one of the most essential neurotransmitter molecules that contributes to happiness or sensation of mental well-being in human beings along with dopamine. However, further research studies have found that serotonin plays multiple other important roles in human body. Let us have a glimpse at it.

    An overview of serotonin- its structure & functions

    Serotonin is a chemical compound that functions primarily as a neurotransmitter and it is found in the brain, gut, and platelets. Low levels of serotonin are linked to depression, while both low and high levels can lead to other physical and psychological health issues, such as serotonin syndrome if there is an excess production or intake of serotonin owing to drug overdosage.

    In addition to its role as a neuro signalling molecule it regulates several important bodily functions, including mood, sleep, gastric motility, blood clotting, sexual and urinary functions.

    The scientific name of serotonin is 5-hydroxytryptamine [5-HT]. Serotonin is produced in brain and intestine and regulates sleep wake cycles, appetite, mood, and inhibits pain. Serotonin is produced in the raphe nuclei of the brainstem and the enterochromaffin cells of the intestinal mucosa.

      The production of serotonin (5-HT) starts in human body using the essential amino acid tryptophan, which undergoes hydroxylation (an oxidation reaction) to 5-hydroxy-L-tryptophan (5-HTP) and decarboxylation to 5-hydroxytryptamine (5-HT). The hydroxylation reaction requires tryptophan hydroxylase, which is considered the rate-limiting enzyme of serotonin production.

    Tryptophan hydroxylase is primarily localized to the raphe nuclei of brain and enterochromaffin cells of the intestinal mucosa, which are the main sites of serotonin production.

    serotonin production is metabolically dependent on vitamin B6 or pyridoxine also.

    Serotonin activity is regulated by its rate of production, release, and metabolism.

    Serotonin is popular as a molecule produced by nervous system which can regulate your mood. But serotonin also plays crucial roles in regulating memory, anger, fear, appetite, stress, addiction, sexual pleasure, sleep, pain perception, cerebral vascular tone, and central respiratory drive.

    This article explores the extra roles played by serotonin in human body functioning.

    Functions of serotonin

    • on brain & nervous system

    Mood and cognition: Helps regulate mood, anxiety, learning, memory, and executive function.

    Sleep and wakefulness: Influences sleep-wake cycles and circadian rhythms.

    •  On digestive system

    Serotonin increases gastric emptying, gut motility, intestinal secretion, and colonic tone. This is very important for proper digestion, absorption and waste removal from gut.

    • promoting insulin secretion
    •  lipogenesis or fat deposition in liver and body parts.
    • Action on lung blood vessels.

          increases pulmonary vascular resistance, and may induce remodelling of the pulmonary vasculature.

    • Act on female reproductive system &urinary functions.

    Serotonin has control over urinary functions, uterine blood vessels constriction, uterine muscle tone, maturation of cells of ovary.

    • Blood clotting:

     Causes blood vessels to narrow (vasoconstriction) at the site of a wound to help form clots and heal wounds & injuries.

    • serotonin is also involved in bone metabolism, liver regeneration, and cell division.

    Serotonin production in human body-Role of gut

     The nutrients received through the foods you consume everyday have pivotal role in regulating your brain functions and thus in contributing to mental & physical health. Your brain produces many types of neurotransmitters or chemicals for its proper functioning through the help of dietary nutrients. These nutrients help the production and functioning of neurotransmitters and nerve cells of brain.

     About 95% of serotonin is produced in the gastrointestinal tract, and the gastrointestinal tract is lined with a hundred million nerve cells, or neurons. It is very clear from this fact that digestive system not only helps to digest food, but also guide the emotions. Therefore, our gastrointestinal tract or gut is considered as our second brain. Problem with gut production and processing of serotonin affect the mood and mental wellbeing.

    The production of serotonin is helped by good gut bacteria of intestinal microbiome. These bacteriae play crucial roles in the health, protecting the linings of intestines.

    Serotonin deficiency and health impacts

    Low serotonin levels are associated with conditions like major depressive disorder, anxiety disorders, and obsessive-compulsive disorder. The detailed list of disorders includes:

    • Depression and other mood problems.
    • Anxiety.
    • Sleep problems.
    • Digestive problems.
    • Suicidal behavior.
    • Obsessive-compulsive disorder.
    • Post-traumatic stress disorder.
    • Panic disorders.
    • Schizophrenia.
    • Phobias[fears].

    Although we are aware only about a few functions of serotonin in human body at present, this neurotransmitter is potentiated to have many other unclear and vague effects on human body. Further extensive research is needed to unravel  the role of serotonin in the body in physiological state as well as in disease.

    What is serotonin syndrome?

    Excessive serotonin activity can cause several pathologic symptoms.It usually happen with drug over intake for managing depression..The symptoms include

    shivering

    Vomiting

    diarrhoea

    Arrhythmias or irregular heart beats

    Agitation

    Excitement

    Increased sweating

    sleeplessness

    Confusion

    Anxiety

    Increased serotonin levels in the body may lead to a potentially life-threatening condition called serotonin syndrome. It is manifested with symptoms ranging from mild shivering, diarrhea, vomiting to severe muscle rigidity, fever, seizures etc..

    How to improve your serotonin levels naturally?

    • Physical exercise

    In order to boost serotonin optimally in your body regular physical exercise is recommended in moderate level.

    Regular exercise definitely helps to boost serotonin levels. Thirty minutes of aerobic exercise five times a week plus two strength-training sessions per week may be adequate to improve the mood problems due to serotonin deficiency.

    • Exposure to sunlight

    Getting exposed to sunlight for around 10 to 15 minutes every day may help to boost not only serotonin levels but vitamin D levels too.

    • Diet

    Eating foods rich in tryptophan, such as nuts, cheese, and red meat, can help the body produce serotonin.

    • Medical treatment

     For people with clinically low levels of serotonin medications are prescribed.

    • Dietary supplements

     Tryptophan, probiotics and SAMe.

            Herbal supplements: These can include ginseng, St. John’s wort, Syrian rue and nutmeg. Further extensive research is needed regarding herbal supplements.

    written by dr sanjana p souparnika

    References for further reading

    1. The expanded biology of serotonin

    Miles Berger 1, John A Gray, Bryan L RothAffiliations ExpandPMID: 19630576 PMCID: PMC5864293 DOI: 10.1146/annurev.med.60.042307.110802https://pubmed.ncbi.nlm.nih.gov/19630576/

    • Yabut JM, Crane JD, Green AE, Keating DJ, Khan WI, Steinberg GR. Emerging Roles for Serotonin in Regulating Metabolism: New Implications for an Ancient Molecule. Endocr Rev. 2019 Aug 01;40(4):1092-1107 https://pubmed.ncbi.nlm.nih.gov/30901029/
    • image courtesy https://www.freepik.com/free-photo/cute-young-sportswoman-giving-advices-how-stay-fit-smiling-joyfully-gazing-friendly-pointing-t-shirt-belly-standing-delighted-pleased-with-happy-look-grey-wall_10152248.htm#fromView=search&page=1&position=31&uuid=6f8f3e9c-8fad-4934-aa0e-3052890e47bc&query=aman+happy+with+better+gut+health

  • Hazel nuts to boost cardiovascular health

    Recently hazelnut has garnered attention of fitness enthusiasts in western countries and Europe due to its potential s to prevent heart attack and stroke. They are rich in vitamin E too.

    Hazelnuts are popular snack ingredient of fitness lovers as it aids in losing weight also. Furthermore, this nut has properties for preventing cardiac diseases and for improving gut health.

    Botanical information

    Hazel nuts are nutrients rich nuts of the hazel tree (Corylus avellana). It is the fruit of the hazel tree and therefore includes any of the nuts deriving from species of the genus corylus especially the nuts of the species corylus avellana.

    A hazelnut cob is roughly spherical to oval in shape and it is about 15–25 millimetres long and 10–15 mm in diameter,. It has an outer fibrous husk surrounding a smooth shell, while a filbert is more elongated.

    As it ripens the nut falls out of the husk. It happens about seven to eight months after pollination. The seed is edible and  can be consumed raw or it can be roasted or ground into a paste.

    Health benefits of hazel nuts

    1.improves digestion

    Hazelnuts are a good source of dietary fiber which helps bowel motility and improves bowel health preventing constipation.

    2. antioxidant potential

    These nuts are rich in vitamin E and the antioxidant help to improve the health of your skin, hair and nervous system.

    3.improves cardiovascular health

    Hazel nuts help to reduce cholesterol and blood sugar level. A few research studies suggest that they are potentiated to reduce insulin resistance.

    Hazel nuts help to reduce the risk for cardiovascular diseases reducing the impact of these risk factors.

    4. used for weight loss

    The role of hazel nuts in obesity reduction is not confirmed. However a few studies with small sample size suggests its role in in weight reduction.

    Hazel nuts as a part of your diet

    It is a nutritious nut that can be included to all your snacks and confectionaries in moderate amounts.You may use hazel nuts with breakfast cereals and salad dressings.

    Caution & safety in consuming hazel nuts

     Generally hazel nuts are very nutritious nuts consumed by the global population. However, there is a caution for use by people having allergy to hazel nuts.

    Written by dr sanjana p

    References

    1.https://pubmed.ncbi.nlm.nih.gov/23415431/

    2.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5188407/

    4.https://www.britannica.com/plant/hazelnut

  •  Solutions for preventing Mild cognitive impairment

     Cognition is a terminology that often come across in our everyday discussions& readings related to thinking and brain functions. What is cognition? How cognitive impairment do occur and what are the ways to prevent cognitive impairment?

     

    Cognition simply refers to any process related to perceiving, thinking, understanding, reasoning and comprehending. According to American psychological association cognition is defined as all forms of knowing and awareness, such as perceiving, conceiving, remembering, reasoning, judging, imagining, and problem solving. Along with affect and conation, it is one of the three traditionally identified components of mind. An individual percept, idea, memory, or the like.

        Cognitive impairment is a condition related to reduced brain functions related to memory, understanding and comprehension. It is a term used for indicating problems with thinking, memory, and judgment, ranging from mild to severe.

     It may eventually affect the quality of life if left untreated. Mild cognitive impairment can often be managed with lifestyle changes and a few simple medications. However, more severe cognitive impairment may impact a person’s ability to perform daily activities. It may present as:

    • Difficulty with thinking and memory &in concentrating, learning new things, or remembering past events.
    • Language and communication also affected. Difficulty in finding the right words or following conversations.

     Therefore, it is crucial to prevent risk factors leading to cognitive impairment. It is not possible to prevent totally, some dementia or severe cognitive impairment causing factors. However, the risk can be considerably reduced by paying some attention to our daily routine and habits.

    Some modifiable risk factors & solutions to prevent cognitive impairment

           Cognitive functioning of brain is dependent on several factors related to our daily lives.

     A few factors leading to cognitive impairment are listed here:

    1] Sleep

     Sleeping for 6-8 hours is crucial for proper functioning and repair of nervous system. Sleep deprivation has detrimental impact on nervous system functioning. How does sleep benefits us in improving the health of nervous system?

    • Sleep plays a crucial role in reducing mental fatigue and helping memory and recall. Studies have proven that lack of sleep affects long-term memory, working memory, attention, higher order executive function, and various decision-making processes. Sleep deprivation can impair memory, recall functions of the brain. Furthermore, it may elevate your stress levels.
    • Sleep is essential for regenerating certain areas of brain

    It is important for brain to continue the regenerative processes within neurons for ensuring proper functioning of brain and nervous system. It happens during sleep hours. Sleep deprivation hampers the regenerative processes.

    • During sleep beta amyloid fibrils are removed by CSF.

      According to research studies during sleep, the cerebrospinal fluid removes the beta-amyloid metabolite in the brain which are harmful to brain functions as they have been implicated in the disease pathology of Alzheimer’s disease. Beta amyloid metabolite is notorious for causing Alzheimer’s disease. That means, sleep deprivation may enhance the risk of Alzheimer’s disease increasing beta amyloid fibril deposition.

    • Brain cell damage is repaired during sleep

    It is during sleep that certain enzymes repair brain cell damage caused by free radicals. Sleep deprivation prevents this repairing process. It is a fact that the brain functions normally because of the neurotransmitters, and neurons that are unable to rest or regenerate.

     Studies have shown that sleep [particularly NREM sleep]is important for turning off the norepinephrine, serotonin and histamine neurotransmitters, which is the time available for receptors to “rest” and regain sensitivity to be more effective at naturally produced levels again.

     Each phase of the sleep cycle has critical role in restoring restores and rejuvenating the brain for optimal function. Normally the glymphatic system of brain eliminate toxins building up with in the nervous system and brain during sleep. It cannot eliminate these toxins that can build up, and negatively affects cognitive abilities, behaviour, and judgment if there is lack of sleep.

    • Lack of sleep also affects your linguistic capacity.

    Temporal lobe of brain is linked with language processing. Sleep deprivation affects it very adversely. Lack of sleep may cause slurred speech due to the brain’s incapacity to process the neuronal signal at optimum levels during waking hours.

    2] Physical activity & exercise to strengthen neuroplasticity potential of brain

    Have you heard about the unique potential of human brain neuroplasticity?  Neuroplasticity is the term referring to the brain’s ability to change, reorganize, or grow neuronal networks. This can involve functional changes due to brain damage or structural changes due to learning. Exercise and physical activity may help to boost it.

    Regular moderate aerobic exercise is an effective solution for improving neuronal health and functional abilities. It is assumed that exercise-induced memory improvement is probably mediated through neurotrophic factors, and exerkines.

     Exerkines are defined as signalling molecules released in response to acute and/or chronic exercise, which exert their effects through various pathways.

     Many organs, cells and tissues release these factors, including skeletal muscle (myokines), the heart (cardiokines), liver (hepatokines), white adipose [fat]tissue (adipokines), brown adipose tissue (baptokines) and neurons (neurokines). Exerkines have potential roles in improving cardiovascular, metabolic, immune and neurological health. Thus, exercising helps your brain power.

       Some brain exercises to improve cognition & memory

    Brain exercises modify neuronal activity in such a way that they may help improvement in memory, cognitive functions or mental abilities.

    Practise the following things to improve cognition:

    • Learning new and complex skills

      Eg: playing instruments, games

    • Solving problems in mathematics
    •  Learning a new language
    •  Recall what you have read
    •  Cooking
    •  Visualization of words, things etc.
    •  Eye- hand coordination activities such as playing tennis, chess etc.
    • Sports games
    • yoga
    •  Meditation
    •  Completing a jigsaw puzzle
    •  Socializing
    •  Increasing vocabulary or word power
    •  Listening to music

    conclusion

    Mild cognitive impairment may affect quality of life overtime or it may progress to more serious forms if not addressed on time with adequate lifestyle changes and some simple medications for a short period of time in cases requiring them.

     In order to prevent this mental catastrophe, make a change or modification in your habits from the very early age.

    Never forget to do physical exercise in your routine; practice brain exercise and ensure that you get adequate sleep.

     It is crucial to understand that erratic sleep may disrupt your memory and other brain functions even if you exercise every day. Therefore, ensure that you sleep for at least 6-8 hours a day.

    Furthermore, yoga & meditation may help to improve health of brain and nervous system.

    Nutrition has pivotal role in maintaining the health of nervous system. Eat healthy follow balanced diet preferably, Mediterranean diet.

    Just include some micro habits to your routine for a big positive change. Enjoy this beautiful world with your senses and maintain your cognitive powers intact!

    References

    1.    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651462/

    2.     https://pubmed.ncbi.nlm.nih.gov/16251949/

    3.  image courtesy : https://www.freepik.com/free-photo/sleeping-young-woman-lies-bed-with-eyes-closed_7728966.htm#fromView=search&page=1&position=7&uuid=b12c4cae-4833-432d-91a0-9d6f652d3a6e&query=sleeping+woman

  • Tangerine

    Tangerines are nutrtious fruits rich in vitamin C , low in calories and fats.& a good source of fiber and important minerals. Have a glimpse into the health benefits of tangerines.

    Do you love to have fresh yummy tangerines? The fruit with sweet to tart taste grow on small trees or shrubs with spiny shoots and evergreen leaves. Tangerines have flowers too. Comparing with oranges, the skin of some varieties of tangerines tends to be loose and peels off more easily. Furthermore, the taste is sourer, or tart, than that of an orange.

     It is easy to recognize good quality tangerines. They will be firm to slightly hard, heavy for their size, and pebbly-skinned with no deep grooves & reddish-orange in color.

    The tangerine are usually cultivated in tropical and subtropical areas. The tree is more tolerant to drought than the fruit. The tree is easily damaged by cold or winter.

    Nutritional facts about tangerines

     These fruits are rich in vitamin C and low in calories and fats. It also a good source of fiber and minerals such as sodium, potassium , calcium and magnesium also. Therefore, tangerines can be a good addition to your healthy diet plan.

    Tangerines also contain antioxidants flavonoids and phenolics. Antioxidants can protect your body against free radicals and many serious illnesses.

    Health benefits of Tangerines

    • Antioxidants to prevent free radical damage to cells

    Tangerines are rich source of vitamin C antioxidant and several other antioxidants which fights against free radicals induced oxidative stress to your body. It is very notorious that free radicals are the morbidity causing agents . They are generated by human body as byproducts of metabolism and a few free radicals reach human body from exposure to environmental toxins. Tangerine antioxidants are potent enough to manage oxidative stress occuring to body. Oxidative stress induced by free radicals is the major cause of many grave chronic diseases.

    • Anti-inflammatory properties

    Tangerines are rich sources of vitamin C and hence protect the body against infections as well as inflammations.

    • Anti-aging properties

      The antioxidants can delay the signs of ageing preventing oxidative stress to cells on the skin and vital organs caused by the free radicals. Antioxidants, particularly vitamin C helps to boost collagen and reduce fine lines and wrinkleson skin

    • Delays age related degeneration

     The vitamins in this fruit prevents age related degenerative changes to skin and vital organs.

    • Antidiabetic properties

    Tangerines can reduce blood sugar levels if consumed in moderate levels.

    • Boosts immunity

    Tangerines are rich in vitamin C and A and therefore helps to boost immunity.

    • Improves digestion

    Fibers in tangerines help to improve digestion

    • Boosts heart health

    Tangerines contain nobiletin antioxidants that helps to improve cardiac function.

  • Figs

     Figs are edible fruits known to us since antiquity and they are available in nature in greenish purple in colors. Of late figs are consumed by more people understanding its nutritional value and the health benefits they provide to human body.

    When you delve deeper into the origin of figs consumption it may date back to ancient times.It is an integral part of Mediterranean diet since many centuries. Indian systems of medicine also use fig for managing reproductive, hormonal and immunological problems.

    Figs [ Ficus carica L] belong to moraceae family. These lush green purple fruits are mostly cultivated in Asian &Mediterranean regions.  It is an integral part of the diet of people residing near Mediterranean sea.

     There are four types of fig fruits, i.e., Caprifigs, Smyrna, San Pedro, and Common figs. Around 800 different fig varieties cultivated in almost 50 countries all over the world.

      Historical significance

    The figs were one of the principal articles of sustenance among the Greeks.

    It was one of the earliest fruit trees to be cultivated, and its cultivation spread in remote ages over all the districts around the Aegean Sea and throughout the Levant.

     Attic figs became celebrated in the East, and special laws were made to regulate their exportation.; the Spartans especially used it at their public tables

      Figs were consumed since ancient times and has great significance in Roman Empire.

    Figs are mentioned in holy books like the Bible and the Quran.

    Nutritional value of figs – A treasure trove of antioxidants

      Figs are well known for their antioxidant, anti-inflammatory and anticancer properties. Figs contain flavonoids, phenolic acids, carotenoids, and tocopherols antioxidants.

    Polyphenols and carotenoids are the two major categories of phytochemicals found in figs. The major classes of polyphenols in figs include phenolic acids, flavones, flavonones, flavonols, anthocyanins, and proanthocyanidins[3].

    Figs are comparatively low in fat. Fig consumption provides moderate number of calories mostly from carbohydrates. However, it can cause blood sugar spike immediately after eating. That is figs are high glycaemic index foods.

    The minerals potassium and magnesium present in figs are crucial for the health of bones and cardiovascular system.

    Figs are good source of vitamins too. They provide thiamine, vitamin B6 and vitamin K and these vitamins are crucial for the health of nervous system and bones. Vitamin K is essential for blood clotting.

    Figs contain calcium, potassium, phosphorus and iron in considerable amounts.

    Figs are rich in fiber and nutrients, and low in calories and hence good for gut health and reducing blood cholesterol.

    A small to medium sized fig provides around 1- 1.45 grams of fiber.

    Epicatechin is the most abundant phenolic compound in dried fig fruits, with a level of 25.4 mg/100 g DW in cultivar “Bela Petrovka” of Ficus carica. Its content is up to three times that of fresh figs. It is a good antioxidant.

    Fig fruits are a rich source of flavonoids antioxidants.

    The major flavonoids found in figs are quercetin and luteolin, which have a total of 631 and 681 mg/kg, respectively. The fruit skin has more flavonoids than the pulp.

    Health benefits of figs

    Figs offer numerous health benefits due to the presence of antioxidants, vitamins and minerals in them.

    • Figs can improve digestive health

    Figs are rich in fibers and helps digestion. It helps to prevent constipation.

    • Figs are good source of antioxidants.

    Phenolic compounds in figs help to reduce oxidative stress to body cells induced by free radicals.

     Anti-oxidants may help to prevent cancer and neurodegenerative disorders of brain including Alzheimer’s diseases, Parkinson’s disease etc. Phenolic compounds in figs can play a significant role in protecting biological cells from hydrogen peroxide free radical damage [5].

    • Figs help bone and heart health

    Figs contain potassium and magnesium in good amounts; they help to sustain heart & bone health.

    • Antimicrobial and anti-inflammatory properties

    Figs are rich in flavonoids and tannins which help to protect from microbial activity and infections.

    Cautionary warnings for fig consumption

    Generally, figs are highly nutritious fruits beneficial to improve health if consumed in moderation.

    However, it is a fruit rich in vitamin K. Vitamin k is a factor helping in blood clotting. However, there is a cautionary warning for those who are on blood thinner medications for cardiovascular events prevention.

     Anticoagulant medications are blood thinners for preventing clots. Those who are on anticoagulant medications must check their vitamin k levels if they are taking figs regularly.

     Fig allergies are common in some people; particularly those who are allergic to birch pollen may have fig allergy. If so, consume fig only after talking to your healthcare provider.

    Excessive eating of figs may cause burning sensation on tongue.

     Figs in your diet plan

    Fresh fig fruits are edible after washing and peeling its outer skin. Dried figs also are commonly eaten after soaking and softening it in water. It can be added into your diet plan in numerous ways.

    • Figs are used as chief ingredient of dessert and smoothies.
    • Figs in salads
    • Fig toast
    • Fig snack bars
    • Fig rolls

    Fig consumption in moderate amounts may boost your digestive, cardiovascular and bone healths. Enjoy the delicious fruit in many ways at frequent intervals in a month.

    References :

    1.  Sarkhosh A., Andersen P.C. The Fig. UF/IFAS Extension. 1994. https://edis.ifas.ufl.edu [Ref list]

    2.  Arvaniti O.S., Samaras Y., Gatidou G., Thomaidis N.S., Stasinakis A.S. Review on Fresh and Dried Figs: Chemical Analysis and Occurrence of Phytochemical Compounds, Antioxidant Capacity and Health Effects. Food Res. Int. 2019;119:244–267. doi: 10.1016/j.foodres.2019.01.055. https://pubmed.ncbi.nlm.nih.gov/30884655/

    3. Vinson J.A. The Functional Food Properties of Figs. Cereal Foods World. 1999;44:82–87. [Google Scholar] [Ref list]

    4. https://fdc.nal.usda.gov/fdc-app.html#/food-details/173021/nutrients

    5. https://onlinelibrary.wiley.com/doi/10.1155/2022/6597092

  • Endocrine disruptors – Chemicals from our daily use products disrupt hormonal balance?

    Have you heard about endocrine disruptors and serious health problems consequent to exposure to these compounds? Endocrine disrupting chemicals (EDCs) are compounds accumulating in human body from environment, food products, personal care products etc.

    Everybody is aware of the devastating impact of plastics on our ecosystems. The chemicals in plastics and various other consumer products are endangering the health of human beings as well as other organisms in the biosphere. Endocrine disruptors are some of these chemical compounds specifically acting o glands and eventually cause life threatening morbidities and disabilities.

    These chemical compounds are grouped under Endocrine disruptors as the name indicates they disrupt the hormonal rhythm of human body. What are these compounds and how do they reach human body?

    Before delving deep into the nature of these chemical compounds let us have a glimpse into the hormonal [ endocrine] system of human body.

    Endocrine system

     The endocrine system plays a pivotal role in coordinating proper functioning of the human body. Hormones play crucial roles in  co-ordinating several biological processes such as growth, metabolism, fertility, and reproduction in humans.

      Hormones are signaling molecules secreted by glands in human body, but cause significant developmental and biological effects in human body with the slightest variation in their levels.

    The major hormones produced by the human body includes thyroid hormones, insulin, pituitary hormones, sex hormones such as estrogen, progesterone, testosterone etc.

    Apart from these, adrenalin, noradrenalin, cortisol are hormones produced by adrenal glands which play crucial role in the body in managing the stress response.

    What are endocrine disruptors?

     Endocrine disrupting chemicals (EDCs) are compounds accumulating in human body from environment, food products, personal care products etc.

    These substances are detrimental to the body as they interfere with the normal functioning of the hormonal system. EDCs can be natural as well as man-made origin and they reach the organ systems through diet, air, skin, and water.

    The importance for awareness about endocrine disruptors

    Recent research studies focus more on endocrine disrupters as these substances show close connection with several serious health problems in males as well as females. It has been pointed out by several previous studies that EDCs cause infertility, nervous system & respiratory system diseases, cardiovascular diseases etc.  Furthermore, EDCs are linked with obesity, diabetes, learning disabilities and several other grave ailments.

     How do endocrine disruptors cause diseases?

      There are various types of endocrine disruptors .Some EDCs can function as “hormone mimics” and the body misinterpret them as hormones and cause disruption in hormonal rhythm of your body. While  a few  other groups of EDCs block natural hormonal functions in the body. All Hormones have specific functions to do in human body and any slightest error can upset the body functions at various levels.

    Some types of EDCs can affect the level of hormones in your blood as they can affect the production, breaking down, or storage of hormones. Moreover, a few EDCs can change the sensitivity of the body to different hormones.

    Common types of endocrine disrupting chemicals [ EDCs]

      The endocrine disrupters have detrimental impact on human body in myriad ways and  quite often it is grave too. According to the Endocrine Society, around 85,000 human-made chemicals in the world, and 1,000 or more of these substances can work as endocrine disruptors. These include

    • Industrial chemicals and pesticides

     Some well-known examples of this category includes DDT, Chlorpyrifos, Atrazine, 2, 4-D, Glyphosate.

     These pesticides reaching the food chain can cause unpredictably grave adverse impacts to the organ systems of human body.

    Perchlorate is a colorless salt manufactured and used as an industrial chemical to make rockets, explosives, and fireworks. This compound can also be found in some groundwater sources and can cause health hazards.

    • Household chemicals

             Lead, Phthalates, Cadmium are a few toxic chemicals reaching from household items of children. Bisphenol A (BPA), Phthalates, Phenol are found in plastics and food storage materials.

    Bisphenol A (BPA) is used to make polycarbonate plastics and epoxy resins. It is used in manufacturing, food packaging, toys, and other applications. BPA resins may be found in the lining of some canned foods and beverages.

    Phthalates are a large group of compounds used as liquid plasticizers. They are found in some food packaging, cosmetics, fragrances, children’s toys, and medical device tubing.

    Some cosmetics of your daily use are sources of phthalates.These include nail polish, hair spray, aftershave lotion, cleanser, and shampoo.

    • Fabrics treated with flame retardants
    •  Cosmetics

    Cosmeticssuch as lotions, products with fragrance, and anti-bacterial soaps etc. Triclosan is an ingredient that was previously added to some antimicrobial and personal care products, like liquid body wash and soaps.

    • Processed foods
    • Soy-based products

    The phyto estrogens in soy products can mimic oestrogen hormone in women of reproductive age group and act as an endocrine disruptor.

    • Industrial solvents and lubricants contain Polychlorinated biphenyls (PCBs) and Dioxins. Also Brominated Flame Retardants.

     PCBs found in building materials are endocrine disruptors.

    (PCBs) were used to make electrical equipment, such as transformers, and are in hydraulic fluids, heat transfer fluids, lubricants, and plasticizers. PCBs were mass-produced globally until they were banned in 1979.

    Endocrine disruptors [EDCs] and their adverse health effects

    Studies that pertain to the impact of EDCs on human health requires cutting edge research in future as corroborative evidences. However, currently it has been found that EDCs can cause:

    • Neurological and behavioral changes
    • Difficulty with stress response.
    • Impact on metabolism
    • obesity and type 2 diabetes
    •  interfere with thyroid function
    • infertility

    Some classes of EDCs (DDT, BPA, phthalates, PCBs, others) can affect reproductive health by mimicking or blocking the effects of male and female sex hormones

    •  affect growth and development
    • High exposures to EDCs during gestation can lead to low-birth weight in infants and developmental problems.
    • Disrupted sexual development
    • Low immunity
    • Cancer

    Exposure to estrogen or androgen mimicking EDCs can promote breast and prostate cancer growth and/or interfere with hormonal cancer therapy

    • Impact of EDCs on fetuses and children

    High exposure to endocrine disrupting chemicals during gestation or pregnancy can have adverse impact on foetus causing developmental delays and numerous other problems in children as they grow over the years.

    Do endocrine disruptor compounds enhance the risk for breast cancer?

    It has been suggested that EDC exposures may potentially increase the risk of breast cancer. It is a fact that most of EDCs are highly persistent in the environment and bio-accumulative. However, it has to be researched meticulously to assess  the long-term impacts of EDC exposures.

     It is recommended that well-designed exposure assessments of potential EDCs in food and food packing are necessary and their potential link to breast cancer development need to be carefully evaluated.

    Phthalates -an important endocrine disrupting chemical  banned by European countries

      Phthalates are chemicals that are used in a variety of cosmetic and personal care products such as hair care products (hair sprays, mousses, and gels), deodorants (including antiperspirants), nail polishes, lotions , skin cleansers, and baby products (oils, lotions, shampoos and diaper creams). The United States and the European Union are currently regulating several phthalates including DEHP and DnBP in children’s products, and it is known that similar action is underway in Canada also.

      According to studies diethyl phthalate (DEP), dimethyl phthalate (DMP), diisobutyl phthalate (DiBP), di-n-butyl phthalate (DnBP) and di(2-ethylhexyl) phthalate (DEHP) were detected mostly in these products.

    The European Union has banned DnBP and DEHP as both are classified in the European Union as category 2 substances to reproduction, which can impair fertility, or if they cause developmental toxicity in humans.

    conclusion 

    It is impossible to avoid or prevent EDCs encroachment into your life and environment as they are part of most of the daily use products; however their impact can be considerably mitigated by deliberate avoidance of those substances which can act as an endocrine disruptor.

    written by dr sanjana p

    References  for further reading:

    1. https://pubmed.ncbi.nlm.nih.gov/33819127/
    2. https://www.sciencedirect.com/science/article/abs/pii/S0013935111000284
    3. Endocrine Society.”Endocrine-Disrupting Chemicals (EDCs) | Endocrine Society.” Endocrine.org, Endocrine Society, 2 February 2024, https://www.endocrine.org/patient-engagement/endocrine-library/edcs
    4. https://pubmed.ncbi.nlm.nih.gov/31719706/
    5. https://pubmed.ncbi.nlm.nih.gov/32903210/
    6. image courtesy-freepik

  • Cinnamon Health benefits

    Are you fond of cinnamon flavour? If so there is a good news about health benefits of cinnamon . Cinnamon may boost your health due to its anti cancer & anti microbial properties

    Cinnamon is an ancient spice ingredient which ruled Indian kitchens and cuisines since time immemorial. Apart from adding flavour to the delicious dishes it is endowed with various health benefits. It is really fantastic to know that beyond its culinary usage as flavouring ingredient to add taste and aroma to Indian foods cinnamon enhances our health at multiple levels.

    The queen of Indian & south Asian cuisines – cinnamon verum

    Cinnamon is known as Cinnamomum verum in the world of botanical science and medicine. It is an evergreen tree that belongs to family Lauraceae .

    Cinnamon used as a spice in Indian kitchens, is derived from its bark. The tree is native to South Asian countries such as India, Sri Lanka and Myanmar (Burma). It is also cultivated in South America and the West Indies. Cinnamon has been known since ancient times. Cinnamomum verum, is native to India, Sri Lanka, Bangladesh and Myanmar. Herodotus, Aristotle and other authors named Arabia as the source of cinnamon.

    The dried inner bark is brown in colour and has a delicately fragrant aroma and a warm sweet flavour. Essential oil of cinnamon is distilled from the bark fragments. Cinnamon oil is used for use in various foods, perfume, and in drugs.

    The main varieties of cinnamon available in Asia include Ceylon cinnamon (Cinnamomum verum), which is chiefly grown in Sri Lanka. It is known as “true” cinnamon. Cassia cinnamon (Cinnamomum aromaticum),is  grown  all over southeastern Asia.

    Cinnamon in the pages of history

    Cinnamon is a  prominent spice used in many rituals & ceremonies  since ancient times. When you turn the pages of ancient world history you may come across several curious facts pertaining to usage of cinnamon. Egyptians used it for embalming and religious practices.

     In medieval Europe many religious rites and rituals were performed using cinnamon as a flavouring agent. During that era cinnamon was a very expensive ingredient in Europe and other parts of the world.

     Cinnamon has an incredible story of inspiring western voyagers like Christopher Columbus and Vasco Da Gama to embark on an expedition to South Asia in quest of this precious spice in 15th century.  It is a fascinating narrative by various travellers of the period that this quest lead to the discovery of new countries and continents.

     Overtime cinnamon conquered the western markets as the most sought after and profitable spice in the Dutch East India Company’s global trade.

    Harvesting & processing of cinnamon

    Cinnamon is an evergreen tree with oval-shaped leaves, thick bark and a berry fruit. While harvesting the spice, the bark and leaves are the main parts of the plant used. The harvesting includes cutting the shoots of the plant close to the ground. In processing, the shoots are first scraped with a semicircular blade and then rubbed with a brass rod to loosen the bark, which is split with a knife and peeled. The peels are telescoped one into another, forming a quill about 107 cm (42 inches) long and filled with trimmings of the same quality bark to maintain a cylindrical shape.

    After this process follows four or five days of drying and the quills are rolled on a board to tighten the filling . Again they are placed in subdued sunlight for further drying for a few days. Finally, they are bleached with sulfur dioxide and sorted into grades.

    Cinnamon is used as an aromatic condiment and flavouring additive in a wide variety of cuisines. The aroma and flavour of cinnamon is due to the presence of essential oil and principal component, cinnamaldehyde.

    Ground cinnamon is 11% water, 81% carbohydrates (including 53% dietary fiber), 4% protein and 1% fat.Since ancient times cinnamon has been in use as part of traditional medicine  primarily in Asian countries.

    Of late many research studies have explored the beneficial effects of cinnamon in Parkinsons, diabetes and neurodegenerative diseases. Cinnamon seems to possess antioxidant, anti-inflammatory, antilipemic, antidiabetic, antimicrobial, and anticancer properties.

    Health benefits of cinnamon

    • Potential to reduce blood glucose levels

    A few small studies suggests that cinnamon helps to lower blood glucose levels. Cinnamon seems to possess an insulin sensitizing action which may help to reduce blood sugar. However, more extensive studies are needed to corroborate these preliminary research findings.

    •      Improves brain health

    The phytochemicals of cinnamon facilitate brain’s ability to utilize glucose.

    Cinnamon helps to limit the Alzheimer induced changes in the brain and modulates the brain insulin signaling also.

    •      Antimicrobial activity

    Cinnamaldehyde in cinnamon possess anti-microbial activity. It can inhibit the growth of Listeria , Escherichia coli, Staphylococcus aureus, fungus like Aspergillus flavus, Mucor plumbeus and yeast species such as Candida lipolytica.

    •      Antioxidant property.

    The antioxidant property is owing to the eugenol component in cinnamon.

    •      Reduces blood pressure

    Cinnamon can reduce high blood pressure.

    •      Anti-cancer effects

    One of the main causations of gastric carcinoma is the gram-negative bacilli Helicobacter pylori (H. pylori).

    Cinnamon extract can decrease the colonization of this  bacteria  in the gut to some extent. However further extensive research is needed in this regard.

    The potential of cinnamon extract to induce apoptosis in tumor cells and also  inhibiting the activity of NFκB accentuate the anti-cancer properties.

    •      Protects from heart diseases

    The  cinnamaldehyde and cinnamic acid protect the heart due to their ability to produce nitric oxide . Also these have anti-inflammatory effect which helps in reducing atherosclerosis or clot and plaque formation within bloodvessels.

     It also helps to prevent high cholesterol.

    Safety & caution

    Cinnamon supplements consumption is safe. Also when cinnamon consumed in small amount generally used in foods as a spice or flavouring agent.

    Excessive consumption or intake for prolonged period of time is associated with side effects such as gastrointestinal problems or allergic reactions.

    Cassia cinnamon contains a chemical called coumarin, which can be harmful to the liver. Huge and prolonged use of cassia cinnamon may cause liver problems.

    written by dr sanjana p

    References

    1.     https://www.britannica.com/plant/cinnamon

    2.     Howard ME, White ND. Potential benefits of cinnamon in type 2 diabetes. Am J Lifestyle Med. 2012;7:23–6. [Google Scholar] [Ref list]

    3.     https://pubmed.ncbi.nlm.nih.gov/24001892/

    4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466762/

  • Star anise antioxidants to prevent lifestyle diseases & obesity

    Star anise one of the flavouring agents of Indian cuisines,has the potential to prevent life style diseases and obesity being the rich source of bioactive compounds.

    Star anise -an overview

    Star anise is familiar to Indian kitchens as one of the key spice ingredients adding flavors to Indian cuisines. It is a fragrant licorice smelling spice used chiefly in cooking Biriyanis and delicious seafood reciipes since antiquity. Star anise is popularly known as “chakra phool” due to its wheel like shape.

    Star anise [illicium verum] is a medium sized evergreen tree native to South east Asian countries, particularly China. The Chinese star anise is well known for its quality and comparatively low propensity to trigger allergy. It is a safe variety of star anise to consume.

    The leaves of the tree are fragrant and the tree yields pink to red flowers also. This spice seed is taken from the fruits of the tree. The fruit is a capsule-like follicetum, star-shaped, reddish-brown, and contains six to eight follicles arranged in a whorl.

    Star anise as a food ingredient provides numerous health benefits. The spice is a treasure-trove of numerous biologically active compounds which protect against various lifestyle diseases afflicting the mankind.

    According to recent medical research studies, this flavoring ingredient offers great health benefits due to the presence of antioxidant compounds within it. Let us have a glimpse at the health benefits star anise provides.

    Health benefits of star anise

    • Antioxidant property

    Star anise contains several types of polyphenols and flavanoids. Phenolic compounds in star anise include p-coumeric acid, gallic aid, cinamic acid, chlorogenic acid and ferulic acid. Catechin and rutin are the major flavonoids. Antioxidants protect against oxidative stress related diseases to body organs such as lifestyle diseases, cancer etc.

    • Antimicrobial &anti-inflammatory properties

     Apart from the antioxidant property to remove oxidative stress to cells of human body, star anise has anti-microbial and anti-inflammatory properties owing to the presence of these compounds in it :

    Linalool

    Quercetin

    Anethole

    Shikimic acid

    Gallic acid

    Limonene.

    Shikimic acid imparts it the antiviral property to fight against viral infections.

     The flavonoid anethole provides it antifungal properties.

    Star anise has the potential to inhibit the production of pro-inflammatory cytokines (Tumor necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β)). It also helps to reduce oxidative stress.

    In a nutshell, star anise protects your body against microorganisms causing inflammations and infectious diseases.

    • Obesity & cholesterol reducing potential

    A study [2] showed that star anise tea consumption significantly reduced the overweight  and BMI. Furthermore, it significantly lowered the levels of serum total cholesterol, triglyceride, LDL and VLDL were observed in the study. It is a hopeful news that star anise helps to decrease bad cholesterol and fat accumulation within the body and prevent heart attacks and strokes chiefly along with other complications of obesity.

    Culinary use of star anise:

    It is used in Indian subcontinent chiefly as a flavoring agent added mostly to various types of Biriyanis and Masala chais. It has an equal significance in Chinese cuisines also as one of the quintessential flavoring ingredients commonly known as”the five spice powder”.

    Caution regarding consumption of star anise :-

    Consume only a very small amount of this spice. Chinese variety is generally safe. Excess intake may cause allergy,

     Copyrighted Dr sanjana p (Dr sanjana vb)

    References

    1. https://biomedpharmajournal.org/vol15no2/antioxidant-and-anti-inflammatory-activity-of-star-anise-illicium-verum-in-murine-model/  Antioxidant and Anti-Inflammatory Activity of Star Anise (Illicium Verum) in Murine Model,Ibrahim S Majal.Department of medical laboratory sciences, Mu’tah University, Karak Jordan
    2. https://pmc.ncbi.nlm.nih.gov/articles/PMC9686881/

  • Green tea -Health benefits

    Green tea is one of the most sought-after health drinks &consumed widely by fitness freaks as well as common people globally. It is consumed for its taste as well as with the goal of achieving better health.

    Green tea is extracted from the leaves of the plant camelia sinensis.Commonly young leaves and budding leaves are used for making this beverage. Green tea intake is beneficial in numerous ways. It is one of the major sources of Catechins which are a type of polyphenol antioxidants with immense health benefits.

    History

    Green tea originated in China in the late 1st millennium BC. From here it spread to various parts of the world as a refreshing and stimulating drink. There are narrations about green tea in ancient Chinese texts about green tea. The book written by Lu Yu [ between 618- 907 AD] describes about the origin of green tea. Another book penned by Zen priest Eisai describes about the stimulant effects of green tea and how it is extracted from the leaves.

    Green tea compounds- Antioxidants

    Green tea contains polyphenols mostly catechins. The four main catechin compounds are (−)-epigallocatechin-3-gallate (EGCG), (−)-epigallocatechin (EGC), (−)-epicatechin-3-gallate (ECG), and (−)-epicatechin (EC).

    Other components include three kinds of flavonoids, known as kaempferol, quercetin, and myricetin.

    Health benefits of green tea on heart, brain & skin

    • Antioxidant potential

    Catechins found in green tea are effective antioxidants potent enough to prevent oxidative stress.

    • Boosts cardiovascular health

    These are capable of preventing atherosclerotic plaque formation in Coronary artery and hence help in preventing heart diseases. This potential of green tea to thwart clot formation in blood vessels to heart and brain help in preventing heart attack and stroke. Furthermore, green tea can reduce can reduce triglycerides and cholesterol levels in the human blood.

    • Prevents sun induced damage to your skin Antioxidant, immunomodulatory, and photo protective functions of green tea make it a great addition to healthy life styles. Green tea helps to protect the skin from sun induced damage and premature ageing. It has immunomodulatory and photo protective effects on skin against UV rays of sun. Catechins in green tea are natural antioxidants that has key role in the prevention of cell damage.
    • Green tea helps to boost cognitive functions of your brain.

    Caffeine, of green tea constituents can improve brain function, including mood, vigilance, reaction time, and memory. Amino acid L-theanine, of green tea can cross the blood-brain barrier.

    Safety /cautionary warnings for green tea consumption

    It is advisable to take only 1-2 cups of green tea a day and in this amount green tea intake is not associated with any detrimental effects to the body. However, if you are sensitive to caffeine green tea may cause tremors or shivering and anxiety.

    Excessive intake may cause liver problems.

    Drug interactions:

    Green tea may interact with nadolol, a beta-blocker used for high blood pressure and heart problems lowering your blood pressure as much as it should. Green tea has presence of vitamin K in small amounts which can interact with proper functioning of blood thinner medicines. Therefore, for patients using beta blocker drugs, and blood thinners like aspirin, clopidogrel etc.  green tea is not a good choice.

    written by Dr sanjana p

    References

    • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843789/
    • https://www.nature.com/articles/srep24353
    •   https://plants.ces.ncsu.edu/plants/camellia-sinensis

  • Ujjayi pranayama to de-stress

    Ujjayi pranayama is a type of breathing exercise of yoga which helps to get rid of your stress, fatigue and invigorate your body and mind.

    ujjayipranayama

    The literal meaning of “Ujjayi” is breath of victory. This pranayama technique is related with victory as the breathing in expands the chest and belly of the person doing this pranayama and the body may resemble to a victorious warrior.  It is one of the important pranayama mentioned in Hata Yoga Pradipika, the ancient classical yoga text.

    Ujjayi pranayama -health benefits

    • It helps to de-stress

    This breathing exercise helps to calm down your nervous system and remove your fatigue and accumulated stress.  You may practice this simple breathing to address the stress of daily life in a positive and effective way.

    • Ujjayi contributes to meditation

    Ujjayi is an integral part of meditative process and it aids to enhance focus and concentration indirectly. Meditation is calming down your nervous system and body to be receptive .Ujjayi helps in this area and as an outcome you may be gifted with better focus and improved concentration.

    •  Helps to improve emotional stability

    Ujjayi pranayama helps to reduce anxiety, agitation and impulsiveness. To get rid of this excessive mental stimulation, is crucial in achieving emotional stability with regular and consistent practice. Only an emotionally stable mind can do better decision making in your career as well as personal life.

    • It improves the energy flow in human body

    According to yoga principles, this pranayama invigorates you by removing energy blocks in your spinal cord. It removes the stagnation of energy and facilitates smooth flow of vital force or energy.

    How to do ujjayi pranayama?

    • The first step is sitting erect with your spine and head straight.
    • closing your mouth and constricting or contracting the throat with slight exertion. Avoid too much contraction of glottis.
    • Now try to exhale and then begin to inhale air slowly and rhythmically. Let the air pass through the constricted throat slowly.
    • Continue inhaling slowly the fresh air, until a sense of fullness is achieved in the chest region. It is good to retain the inhaled air for a period of 6 seconds.
    •  Now exhale spontaneously. Please try to exhale slowly and it is advisable to avoid jerky or hasty movements.
    • At the end of it,breath normally in a relaxing way.

     

    How does ujjayi breathe work for human body beneficially?

        This breathing technique is capable of generating body heat with in. Actually, it is the friction of the air, going down the contracted upper airway to both lungs is generating the heat. It is soothing for all vital organs & particularly aids in stimulating the fatigued brain. Therefore, Ujjayi is also referred to as “Psychic breath”.

    Ujjayi is beneficial in enhancing the capacity of your lungs. The airflow through constricted throat in this type of pranayama, compels the lungs to expand fully during inhalation of air.  This maximum expansion helps increased oxygen transfer to various parts of the body.

    The ujjayi pranayama is done slowly and rhythmically and it calms down the para sympathetic nervous system and brings about calmness at mental level.

    While doing ujjayi pranayama certain vibrations in the larynx stimulate sensory receptors and it may signal the Vagus nerve. The whole process helps to calm down the mind and body.

        The contraction of glottis throat] produced in Ujjayi pranayama exerts a gentle pressure on the carotid sinuses in the neck also, which is regulating blood pressure in the arteries. This may affect to reduce stress and slow down the excessive thinking activity.

    Who should not do Ujjayi pranayama?

    • Individuals having high blood pressure & heart diseases better avoid doing this pranayama.
    •  Never over do the contraction of glottis

    While doing this breathing exercise, exert only a little contraction of throat so that the air flow through channel is streamlined and a little friction is generated. This is generating the adequate heat or energy. Too much exertion is the erroneous method of doing this breathing exercise and is associated with various disadvantages and adverse effects. Be cautious to be gentle.

     writtenby dr sanjana p [copyright]

    References

    • https://www.yogajournal.com/practice/yoga-sequences/what-is-ujjayi/
       
      https://www.sciencedirect.com/science/article/pii/S0975947621001388